PPBP and HIV infectious disease: Various markers of platelet activation, several mentioned above, have been found to be upregulated in HIV-infection and include CD62P, CD40L, GPIV, RANTES, neutrophil activating peptide-2 (NAP-2), and LIGHT [homologous to lymphotoxin, inducible expression, competing for GpD of herpes virus, that binds to the HVEM, and is expressed on activated T-lymphocytes and platelets (also known as tumor necrosis superfamily 14)] (127, 130, 132–135).