• Neutropenia (99) due to increased peripheral neutrophil apoptosis, calpains (64). • Impaired CD62L, increased CD11b and CD18 expression (100). • Reduced chemotaxis and recruitment (32, 101). • Reduced phagocytosis (26, 33). • Reduced production of granular proteins and peptides (90). • Reduced ROS production (33). • Reduced cytokine production (102, 103). The gene discussed is ITGB2; the disease is Decreased total neutrophil count.