FOXP3 and asthma: In a similar manner, delivery of the dectin-1/TLR2 agonist curdlan (181), a bacterial cell wall exopolysaccharide, to asthmatic mice induces differentiation of IL-10-expressing, Maf+Foxp3− Treg (i.e., Tr1 cells), and thereby reverses the animal’s asthma phenotype (182).