Moreover, two cytokines of group 1, IFN-γ and TNF-α, also associated with the CSF of patients with progressive MS with a high degree of meningeal inflammation and a high number of cortical lesions (29), play a crucial role in enhancing excitatory synaptic transmission (30, 31), thus favoring neurodegeneration (17). Here, TNF is linked to myeloid sarcoma.