It was not until the end of the 20th century and beginning of the 21st that the field of immunotherapy was revitalized with several key discoveries, including the identification of tumor-associated antigens, the use of recombinant cytokines such as IL-2, tumor-specific monoclonal antibodies, adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) (8), dendritic cell vaccines (9), chimeric antigen receptor (CAR) T cells (10), and immune checkpoint inhibitors (ICI) (11). The gene discussed is IL2; the disease is neoplasm.