With the development of detection methods such as mass cytometry, 2 NK cell subsets (CD16+CD8+CXCR3+ and CD16+CD8+CXCR3+CD11c+) were recently identified in patients at high risk for developing T1DM that can potentially serve as predictive biomarkers for the disease (42). This evidence concerns the gene CXCR3 and type 1 diabetes mellitus.