For example, it was reported that NK cells limit the destruction of pancreatic β cells and contribute to T1DM remission by decreasing the numbers of autoreactive cytotoxic T cells (191); and a later study showed that increasing the proportion of NKG2D+ NK cells and inducing IFN-γ secretion in this population which enhancing the protective effect of complete Freund's adjuvant (CFA) in NOD mice (192). The gene discussed is KLRK1; the disease is type 1 diabetes mellitus.