A bias in functional NK cell subsets has been observed that may be correlated with the development and progression of T1DM; although the number of CD3−CD56+ NK cells is reduced in patients with longstanding T1DM, there were no differences in the ratio of CD56high/CD16− and CD56low/CD16+ NK cells between patients with longstanding or recent-onset T1DM and controls (195). The gene discussed is FCGR3A; the disease is type 1 diabetes mellitus.