The overexpression of IL-12 in SS was also shown to participate in the differentiation of helper T (Th)1 cells and IFN-γ production (74, 75); and activation of IFN signaling and the recruitment of pDCs to the salivary glands of pSS patients may promote NK cell activation and IFN-γ production, thereby aggravating disease pathogenesis (71, 76, 77). The gene discussed is IFNG; the disease is peeling skin syndrome.