IFNG and myeloid sarcoma: Through a mechanism involving KIR two Ig domains and long cytoplasmic tail (KIR2DL)4-HLA-G–mediated conjugation of human NK cells and oligodendrocytes (OLs), activated NK cells were polarized to express IFN-γ and exert cytotoxic effects against OLs, suggesting a mechanism by which NK cells promote MS pathogenesis (160).