Although the molecular mechanisms of HS and HF on the immunologic micromilieu are not fully elucidated, different mechanisms of HF and HS diet, such as altered renal lipid metabolism and increased expression of sterol regulatory element-binding proteins in HF diet (41) and increased activity of intrarenal renin-angiotensin system in HS diet (25), have been reported to contribute to enhanced intrarenal inflammation. This evidence concerns the gene CNBP and hydrops fetalis.