Overall, our results corroborate the hypothesis that the Th2 response is associated with protection against neurological manifestations in arbovirus infections, as evidenced by: i) the modulation of the immune response exerted by IL-10, ii) the correlation between IL-6, IL-2, and IL-5, but not IL-17A, and iii) the high levels of IL-4, IL-2, and IL-5 molecules in the serum of non-neurological patients. Here, IL4 is linked to arbovirus infection.