Since SCA is considered a sterile inflammatory disease, the assessment of the TLRs expression, as well as the analysis of checkpoints in immune cell subsets along with quantification of other cytokines (IL-1a, IL-18, and IL-33), would provide a more detailed description regarding the inflammasome activation in order to more fully understand SCA pathophysiology and allow for the identification of novel prognostic factors. This evidence concerns the gene IL18 and autosomal dominant cerebellar ataxia.