RASSF1 and cancer: This signaling pathway also plays a role in cell-cycle mediation and in the induction of apoptosis, and is thought to be tumor-suppressing given the silencing of Rassf1 and somatic mutation of MAP3K in many cancers (Vos et al., 2000; Agathanggelou et al., 2005; Donninger et al., 2007; Stark et al., 2011).