ARAF and neoplasm: Polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) are multi-domain megasynthases involved in the biosynthesis of a remarkable amount of biological active compounds clinically valuable as anti-microbial, anti-fungal, anti-parasitic, anti-tumor and immunosuppressive agents (Cane and Walsh, 1999) and, therefore, require special attention.