Subsequently in a case-control study of 216 unrelated patients with adrenocortical tumors (including PPNAD, PBMAH, CPAs, non-secreting adrenocortical tumors, and ACC) and 192 controls, nine different PDE8B sequence changes were found in the patients and controls with two variants that were identified only in the patient group demonstrating significant potential to impair protein function in vitro and in silico (76). Here, PDE8B is linked to adrenal cortex neoplasm.