POMC and Cushing syndrome due to macronodular adrenal hyperplasia: Adrenal cortisol secretion in this disease was initially considered to be ACTH-independent and thus this form of BAH was formerly called ACTH-independent macronodular adrenal hyperplasia (AIMAH); however, studies have since demonstrated that ACTH secretion from clusters of adrenocortical cells in PBMAH may in part regulate cortisol secretion by paracrine action (80).