PRKAR1A defects have not been identified in PBMAH, however somatic losses of the 17q22–24 region in PBMAH lead to PKA subunit and enzymatic activity changes and altered PKA signaling that is similar to that of other adrenal tumors with PRKAR1A defects or 17q losses (119). Here, PRKAR1A is linked to adrenal gland neoplasm.