-Middle age, mild hypercortisolism and/or mineralocorticoid excess-Associated with MEN-1, FAP, MAS, HLRCC, isolated (AD)-Most lesions have aberrant GPCRs (vasopressin, serotonin, catecholamines, GIP, luteinizing hormone)-PBMAH carry the ability of intra-adrenal production of ACTH with an autocrine/paracrine effect on glucocorticoid or mineralocorticoid production. The gene discussed is POMC; the disease is hereditary leiomyomatosis and renal cell cancer.