EDN1 and diabetes mellitus: The results of the present study revealed that ET-1 in the diabetes group (147.15 ± 10.26 pg/mL) was significantly higher than that in the control group (74.38 ± 4.27 pg/mL) (P < 0.05) and that NO in the diabetes group (76.39 ± 6.37 μmol/L) was significantly lower than that in the control group (91.31 ± 2.06 μmol/L) (P < 0.05).