FMD and NO were found to exhibit a significant negative correlation with diabetes duration/HbA1c (P < 0.05) and endothelin-1 (ET-1) and a significant positive correlation with diabetes duration/HbA1c (P < 0.05) (Table 3); by contrast, such correlations exhibited no significance in the control group (P > 0.05). The gene discussed is EDN1; the disease is diabetes mellitus.