Hemostatic markers such as the von Willebrand factor and plasminogen activator inhibitor-1 and elevated endothelial dysfunction/activation biomarkers, including E-selectin, adhesion molecules, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, predicted an increased T2DM risk independent of other risk factors for diabetes mellitus. Here, SELE is linked to type 2 diabetes mellitus.