Hemostatic markers such as the von Willebrand factor and plasminogen activator inhibitor-1 and elevated endothelial dysfunction/activation biomarkers, including E-selectin, adhesion molecules, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, predicted an increased T2DM risk independent of other risk factors for diabetes mellitus. The gene discussed is ICAM1; the disease is type 2 diabetes mellitus.