Moreover, the major susceptible HLA class II haplotype in Japanese associated with AP III was DRB1*04:05-DQB1*04:01 (87), and the haplotype DRB1∗09:01 was associated with the co-occurrence of T1D and AITD in Japan (88). The gene discussed is HLA-DRB1; the disease is type 1 diabetes mellitus.