• IDegAsp can be initiated directly in any (insulin-naïve) patient who have not achieved adequate glycemic control despite optimal OADs (metformin, 2OADs, 3OADs)• IDegAsp may be initiated as BID in case of unacceptable PPG is apparent at two mealtimes• HbA1c levels >2% of the individualized HbA1c target and/or• HbA1c >8.5% (HbA1c ≥7.5% despite metformin for T2D children)• Also in patients using basal insulin who need a better post-prandial glycemic control. This evidence concerns the gene INS and type 2 diabetes mellitus.