• Failure to achieve an individualized HbA1c target as accompanied with high FPG or high PPG under optimally titrated (3–6 months) basal insulin treatment• To obtain lesser rate of nocturnal hypoglycemia• The switching should be performed 1:1 without dose reduction• The dose titration should be based on FPG values as well as PPG values after the meal with injection, as measured at lebull weekly. This evidence concerns the gene INS and Hypoglycemia.