Moreover, in patients without diabetes, the IL-2R/IL-6 and TNF-α/IL-6 ratios increased greatly in week 2 compared to that in week 1 (P=0.004 and P=0.0005, respectively), indicating that the imbalance of Th1/Th2 ratios recovered to some degree in week 2 in patients without diabetes, while there was no difference in patients with diabetes between week 1 and week 2. Here, TNF is linked to diabetes mellitus.