However, and contrary to our expectations, based on these observations as well as those by others, we also discovered that pharmacologic inhibitors of NE [AZD9668 (41)] and MPO [AZD5904 (42)], alone or in combination, were ineffective in delaying and/or preventing the progression of T1D towards overt hyperglycemia. This evidence concerns the gene MPO and type 1 diabetes mellitus.