Even though NE and MPO would be expected to be attractive targets in order to delay the pathology inside the pancreas that predisposes to the peripheral autoimmune trigger, treatment of early age NOD mice with AZD9668 (NE inhibitor) or AZD5904 (MPO inhibitor), alone or together, was unable to delay the time at onset or prevent the progression towards overt hyperglycemia any better than control in NOD mice. This evidence concerns the gene MPO and Hyperglycemia.