CPT1A and Wilson disease: Importantly, 7KC significantly decreased mRNA expression of Cpt1a in WD compared to WD+7KC (0.8 ± 0.2 vs. 0.5 ± 0.2; p < 0.05, Figure 3C) and mitochondrial complex I activity tended to decreased in WD+7KC (Supplemental Figure 1A).