Anti-AQP4-IgG positive and negative patients demonstrated no significant difference in the “Multiple Sclerosis Functional Composite (MSFC)” with a P of 0.68 (mean 7.96 vs. 8.21; median nine for both; range 4–9 for both; SD 2.07 vs. 1.87; 95% CI 7.08–8.83 vs. 7.31–9.11; N = 24 vs. 19) as shown in Supplementary Figure 7D. Here, AQP4 is linked to multiple sclerosis.