Spreading cortical depression or spreading brainstem depression (53) are theorized to cause migraine aura (in this case, vertigo, dizziness, and auditory dysfunction) and symptoms that ultimately result also in substance P release from the trigeminal ganglion, leading to vasodilation, increased vascular permeability, and extravasation of plasma and neurogenic inflammation (54–56). Here, TAC1 is linked to migraine with aura.