Activation of PAR2 is intimately related to the coagulation cascade, and mice lacking the Par2/F2rl1 gene show reduced fibrin deposition in bleomycin-induced lung injury and glomerular nephritis (Moussa et al., 2007; Borensztajn et al., 2010; Bardou et al., 2016). This evidence concerns the gene F2RL1 and injury.