Here, we investigated whether PAR2 activation, reported to be involved in coagulation, inflammation, fibrosis and infection, could potentially promote the TF-mediated clotting cascade in the vicinity of the kidneys (Vesey et al., 2007a, 2013; Adams et al., 2011; Chung et al., 2013; Oe et al., 2016). Here, TF is linked to infection.