PIK3C2A and acute kidney injury: Mohamed et al. (2020) found high levels of plasmatic creatine phosphokinase (CPK), above 1000 U/L in more than 30% of their patients. In most cases, values were not as high as in typical rhabdomyolysis-induced AKI (above 15,000 IU/ml) (Bosch et al., 2009). Pigmented casts were also found in 3 out of 26 autopsy analysis of kidney tubules from deceased patients with high CPK levels (Su et al., 2020).