The RT-qPCR results showed that ghrelin reduced the mRNA expression of GPR78, CHOP, and BAX and increased the mRNA expression of Bcl-2 in a dose-dependent manner in mice colitis models, and such an effect of ghrelin could be reversed by [D-lys3]-GHRP-6 (Figures 4A,B). Here, BCL2 is linked to colitis.