The inhibitory effects of MEG3 overexpression on RA pathology might be achieved by the increase of chondrocyte proliferation rate, through the negative regulation of miR-141 and AKT/mTOR signaling pathway (Li et al., 2019a; Chen et al., 2019b; Lu and Qian, 2019). This evidence concerns the gene AKT1 and rheumatoid arthritis.