Circulating lnc-ITSN1-2 has a high diagnostic value for RA, and the disordered expression of lnc-ITSN1-2 may be a new marker for RA diagnosis and disease treatment (Lee and Bae, 2018; Yue et al., 2019) (Figure 1). Here, ITSN1 is linked to rheumatoid arthritis.