H19 and rheumatoid arthritis: The increased sensitivity of overexpressed H19 RNA to starvation/cytokine regulation in RA indicated that embryo genes were involved in the pathogenesis of RA, which reflect the embryonic dedifferentiation and continuous inflammation in synovial tissue (Stuhlmüller et al., 2003; Jarroux et al., 2017; Yang et al., 2020).