NLRP3 and Parkinson disease: Other regulators of NLRP3 inflammasome activation, with implications for PD etiology, include the long noncoding RNA, lncRNA-Cox2, which regulates both autophagy and microglial NLRP3 inflammasome activation via binding to NF-κB, inducing its translocation to the nucleus and upregulation of NLRP3 related genes (Xue et al., 2019).