A recent report found that OLT1177, a β-sulfonyl nitrile molecule, is a selective inhibitor of the NLRP3 inflammasome, and in fact reduces Fyn kinase levels by 35% in human monocyted derived macrophages following stimulation with LPS and nigerecin (Marchetti et al., 2018), and thus could be beneficial in both AD and PD. This evidence concerns the gene NLRP3 and Parkinson disease.