NLRP3 and Parkinson disease: Furthermore, a recent study demonstrated that the stimulation of mitophagy, in a murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced PD model, in an attempt to aid in clearance of damaged mitochondria suppressed NLRP3 inflammasome activation in microglia, reducing inflammation, dopaminergic neuronal loss and improving behavioral parameters (Ahmed et al., 2020).