A recent report found that OLT1177, a β-sulfonyl nitrile molecule, is a selective inhibitor of the NLRP3 inflammasome, and in fact reduces Fyn kinase levels by 35% in human monocyted derived macrophages following stimulation with LPS and nigerecin (Marchetti et al., 2018), and thus could be beneficial in both AD and PD. The gene discussed is NLRP3; the disease is Alzheimer disease.