In fact, some studies indicate that different regulatory mechanisms control IL-1β and IL-18 secretion (Schmidt and Lenz, 2012; Zhu and Kannegant, 2017; Christgen et al., 2020), which is an important consideration in understanding their effects in several neurological disorders, including HD (Motta et al., 2007; Chang et al., 2015; Tzeng et al., 2018; De Biase et al., 2020). Here, IL1B is linked to Huntington disease.