1) plasma MIF levels were elevated in non-severe AP (1.68 ± 2.04 ng/ml) and severe AP (6.04 ± 4.05 ng/ml) than healthy controls (0.51 ± 0.23 ng/ml); 2) prognostic utility of plasma MIF in discriminating severe AP from non-severe AP and healthy controls: Cut-off (> 2.30 ng/ml), AUC (0.950), Se = 0.962, Sp = 0.803. This evidence concerns the gene MIF and alkaline phosphatase measurement.