1) ISO-1 alleviated pathological injury of pancreas and lung, attenuated serum levels of IL-1β, IL-6, and TNF-α, inhibited activation of lung p38 MAPK and NF-κB in AP rats; 2) ISO-1 reduced MIF expression, increased expression of p38 MAPK, p-p38, NF-κB, as well as TNF-α and IL-1β levels of fetal kidney tissue in AP rats. The gene discussed is NFKB1; the disease is alkaline phosphatase measurement.