1) peripheral leukocyte mRNA levels of MIF in AP patients were 6.5-fold higher than healthy controls; serum MIF levels in AP patients were 10.3-fold higher than controls; 2) prognostic utility of serum MIF: Severity: Cutoff (>1,186 pg/ml), AUC (0.71), Se = 0.47, Sp = 0.93, p < 0.01. Necrosis: Cutoff (>2,707 pg/ml), AUC (0.55), Se = 0.23, Sp = 0.95, p = 0.47. Death: Cutoff (>633 pg/ml), AUC (0.84), Se = 1.00, Sp = 0.61, p < 0.01 Here, MIF is linked to alkaline phosphatase measurement.