IL6 and alkaline phosphatase measurement: A most recent study (Shen et al., 2021) demonstrated that MIF at a cut-off value of 2.3 ng/ml has the best discriminative power (AUC, 0.950; 95% CI, 0.914–0.987) for predicting severe AP which was higher than Acute Physiology and Chronic Health Evaluation II (AUC, 0.899), Bedside Index for Severity in Acute Pancreatitis (AUC, 0.886), and serum IL-6 (AUC, 0.826).