circEGLN3 promotes the proliferation and aggressiveness of RCC via miR-1299-mediated IRF7 activation (Lan et al., 2019; Lin and Cai, 2020) The up-regulated circDHX33 can promote the proliferation and invasion of RCC, by sponging with miR-489-3p and increasing mitogen-activated protein kinase (MEK) expression (Wang et al., 2020). The gene discussed is MAP2K7; the disease is renal cell carcinoma.