Besides the already mentioned positive effects of the selective FXR ligand OCA on many parameters of MetS in the FLINT trial (Neuschwander-Tetri et al., 2015), in the last decades intensive research has been done on the relation between FXR and the peroxisome proliferator-activated receptors, as reviewed in different publications (Cave et al., 2016; Lee, 2016; Preidis et al., 2017). This evidence concerns the gene NR1H4 and metabolic syndrome.