APP and Alzheimer disease: Within cerebellar cortex, diffuse APP/Aβ and Aβ42 deposits were mainly found in the ML, with few scattered APP/Aβ deposits in the GL, PC layer, and white matter in both DS (Cole et al., 1993; Li et al., 1994; Cataldo et al., 1996; Mann et al., 1996) and AD (Pro et al., 1980; Joachim et al., 1989; Ogomori et al., 1989; Lemere et al., 1996; Wang et al., 2002; Mavroudis et al., 2010; Sepulveda-Falla et al., 2014; Catafu et al., 2016; Jacobs et al., 2018).