PCSK9 and Hypercholesterolemia: In a large European cohort (n = 3,673), sex has been shown as a strong predictor of PCSK9 and different variables have been associated with PCSK9 in a sex-specific way, e.g., mean corpuscular hemoglobin concentration and smoking habits are PCSK9-independent predictors in women, whereas hypercholesterolemia and physical activity are independent predictors in men (Ferri et al., 2020).