Studies have implicated changes in the expression of REST, as well as REST-dependent genes, in the specific brain regions and several brain diseases, including Alzheimer’s disease, Huntington disease, Parkinson’s disease, ischemia, epilepsy, and depression (Goswami et al., 2010; Baldelli and Meldolesi, 2015). Here, REST is linked to early-onset autosomal dominant Alzheimer disease.