Fu et al. (2019) noted that abnormal proinflammatory cytokine expression and microglia morphology could be changed by silencing miR-155. In addition, a miR-155 antagomir may reduce microglia-impaired neuron excitability and attenuate KA-induced epilepsy by inhibiting microglia activation (Fu et al., 2019). Moreover, inhibition of miR-155 could also attenuate MMP3 overexpression after IL-1β stimulation in astrocytes, suggesting a possible strategy to prevent epilepsy via the modulation of glial cells and reduction of inflammation (Korotkov et al., 2018). This evidence concerns the gene MMP3 and epilepsy.