CSF NfL showed good diagnostic value across different studies on prion disease and full discrimination between CJD patients and controls (AUC 0.949–1.000) (Steinacker et al., 2016; Kovacs et al., 2017; Abu-Rumeileh et al., 2018b; Zerr et al., 2018). The gene discussed is NEFL; the disease is Creutzfeldt Jacob disease.