MAPT and Creutzfeldt Jacob disease: Brain magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) surrogate markers such as proteins total (t)-tau and 14-3-3, and electroencephalographic (EEG) examination, support the clinical diagnosis of probable CJD according to current criteria (Zerr and Parchi, 2018; Rhoads et al., 2020).