Interestingly, CSF NfL, either alone or in combination with other biomarkers, yielded a performance similar to t-tau in the distinction of prion disease from other NDs (AUC 0.926 vs. 0.939) and showed even a higher diagnostic value than t-tau in the specific comparisons between atypical prion disease and other rpNDs (AUC 0.839 vs. 0.722) (Abu-Rumeileh et al., 2018b). The gene discussed is NEFL; the disease is prion disease.