The pathogenesis of prion diseases relies on the templated seeded conversion of the cellular prion protein (PrPC), encoded by the prion protein (PRNP) gene, into a pathological isoform with abnormal conformation (PrPSc), which shows a tendency to aggregate and forms amyloid fibrils (Parchi and Saverioni, 2012; Puoti et al., 2012; Baiardi et al., 2019). Here, PRNP is linked to prion disease.