Abnormal mTOR activities have been associated with several genetic forms of ASDs, including Tuberous Sclerosis Complex (TSC), Phosphatase and tensin homolog (PTEN), Hamartoma Tumor syndrome, Fragile X syndrome, RASopathies, Angelman Syndrome, Rett Syndrome, and Phelan-McDermid syndrome (Bhattacharya et al., 2012; Costa-Mattioli and Monteggia, 2013; Jülich and Sahin, 2014; Winden et al., 2018). Here, PTEN is linked to atypical Rett syndrome.