In this study, we have demonstrated that circulating NF-κB, TNF-α, IL-6, PTX-3, PCT, and CRP levels in breast and colon cancer were significantly higher than in control groups and NF-κB levels were positively correlated with IL-6, PTX-3, PCT, and CRP in all patients. This evidence concerns the gene NFKB1 and colonic neoplasm.