Normally, IL-1 is expressed and regulated in the disc cells through a balance of activating and inhibiting receptors (IL-1RI and IL-1Ra, respectively), in the case of disc degeneration, this process becomes unbalanced (local overproduction of IL-1RI and/or underproduction of IL-1Ra) [20]. Here, IL1A is linked to intervertebral disk degenerative disorder.