CASP3 and neoplasm: In 2020, Liu et al. reported that CAR T cells rapidly activated caspase-3 in target cells by releasing GzmB, and then the caspase-3/GSDME-mediated pyroptotic pathway was activated, causing extensive pyroptosis.194 More recently, researchers found that GzmB directly cleaved GSDME and induced pyroptosis, further activating the antitumor immune response and inhibiting tumor growth.19 Subsequently, it was reported that natural killer cells and cytotoxic T lymphocytes (CTLs) killed GSDMB-positive cells by pyroptosis.