Targeting the ROS/NLRP3 inflammasome/IL-1β signaling pathway may be helpful for 5-FU adjuvant chemotherapy in OSCC.436 Bay 11–7082 can inhibit the NLRP3 inflammasome,437 blocking the cell cycle progression of gastric cancer cells, which provides a basis for its clinical application in gastric cancer.438 The expression of ASC protein in metastatic melanoma is lower than that in primary melanoma. This evidence concerns the gene NLRP3 and melanoma.