GSDME and melanoma: It also reveals a potential iron-based intervention strategy for treatment of melanoma patients.112 In addition, eEF-2K regulated the pathway linking autophagy and pyroptosis.209 Inhibition of eEF-2K makes melanoma cells more sensitive to doxorubicin.209 However, the specific mechanism of eEF-2K regulating GSDME remains to be studied.209 It has been reported that melanoma cells overexpressing GSDMB show obvious characteristics of pyroptosis.