AIM2 and cervical carcinoma: Indeed, normal cervical epithelial cells released less IL-18 and IL-1β than cervical cancer cells.397 Sirtuin 1 (SIRT1) was overexpressed in HPV-infected cervical cancer cells, and knocking down SIRT1 caused cervical cancer cells to undergo pyroptosis, as well as highly express AIM2 and its downstream genes associated with the inflammasome response.