CASP3 and neoplasm: Wang et al. and Rogers et al. found that chemotherapy drugs induced the activation of caspase-3 in tumor cells with high GSDME expression and induced pyroptosis.16,17 In tumor cell lines with low expression of GSDME, decitabine can upregulate GSDME expression and increase the sensitivity of tumor cells to chemotherapy drugs, thus making these cells more prone to pyroptosis16,17 (Fig. 4).