GSDME and hepatocellular carcinoma: DFNA5 overexpression resulted in the inhibition of cell proliferation.334 Furthermore, berberine inhibited the viability of HepG2 cells through caspase-1-mediated pyroptosis.335 Interestingly, caspase-1-mediated pyroptosis may also play a role in APOL1-induced cytotoxicity.336 A great deal of evidence has confirmed that NLRP3 inflammasome is associated with liver failure and liver disease.337,338 In a previous study, Wei et al. found that the loss of the NLRP3 inflammasome contributed to the progression of hepatocellular carcinoma.