STAT3 and gastric cancer: Similarly, the expression level of GSDMD was low in gastric cancer cell lines and models.306,308 In addition, the downregulation of GSDMD could activate the signal transducer and activator of STAT3 and PI3K/PKB signaling pathways, and regulate cell cycle-related proteins to accelerate S/G2 phase cell transition, suggesting that GSDMD downregulation may be beneficial for the treatment of gastric cancer.309 It was found that chemotherapeutic drugs induced pyroptosis rather than apoptosis in gastric cancer cells with high expression of GSDME.