Obesity was related to the elevated risk of ER-positive breast cancer.268–270 Generally, tumor microenvironment in obese patients recruited tumor infiltrating myeloid cells with the activation of NLRC4 inflammasome, and causes the production of IL-1β.271 IL-1β promoted the progression of breast cancer through adipocyte-originated angiogenesis and the expression of vascular endothelial growth factor A (VEGFA).271 In 2020, Jiao et al. found NLRP1 inflammasome was involved in breast cancer cell pyroptosis triggged by human umbilical cord MSCs (hUCMSCs)-CM. This evidence concerns the gene VEGFA and obesity due to melanocortin 4 receptor deficiency.