Targeting the ROS/NLRP3 inflammasome/IL-1β signaling pathway may be helpful for 5-FU adjuvant chemotherapy in OSCC.436 Bay 11–7082 can inhibit the NLRP3 inflammasome,437 blocking the cell cycle progression of gastric cancer cells, which provides a basis for its clinical application in gastric cancer.438 The expression of ASC protein in metastatic melanoma is lower than that in primary melanoma. Here, NLRP3 is linked to metastatic melanoma.