In primary melanoma, ASC inhibits tumorigenesis by reducing the phosphorylation of IKKalpha/beta and inhibiting the activity of NF-kappaB.212 ASC has a pro-inflammatory effect on infiltrating cells, which is beneficial to the development of melanoma, but it also limits the proliferation of keratinocytes to respond to harmful stimuli, possibly by activating p53 to inhibit melanoma.439 In addition, antioxidants inhibit the production of ROS, suggesting that they block the expression of NLRP3. The gene discussed is CHUK; the disease is melanoma.