NLRC4 and obesity due to melanocortin 4 receptor deficiency: Knockdown of AIM2 resulted in the inhibition of cell growth and apoptosis in OSCC cells, while B cells activation was downregulated by nuclear factor kappa-light-chain enhancement.442 Furthermore, the NLRC4 inflammasome activation/IL-1a signaling pathway, which is associated with obesity, promoted the progression of breast cancer, which provided a mechanism by which obesity can promote the progression of breast cancer.