NLRP3 and neoplasm: In addition, flagellin A N/C inhibited radiation-induced ROS production in intestinal epithelial cells, reduced NLRP3 activity, and suppressed caspase-1-dependent pyroptosis, which may be a factor in protecting intestinal epithelial cells from radiation damage.454 These studies show the negative effects of pyroptosis in chemotherapy and radiotherapy, which offer new insight and hope to tumor treatments.