In addition, 17β-estradiol (E2) suppressed the tumor progression of hepatocellular carcinoma by activating the NLRP3 inflammasome.339,340 In 2019, that group demonstrated that E2-induced activation of the NLRP3 inflammasome resulted in caspase 1-mediated pyroptosis.341 Besides, targeting the NLRP3 inflammasome may exert inhibitory effects on proliferation, metastasis, and invasion of hepatocellular carcinoma,342 indicating that it is necessary to understand the exact mechanism of inflammasome in the proliferation, metastasis and aggression of hepatocellular carcinoma. This evidence concerns the gene NLRP3 and neoplasm.