Indeed, normal cervical epithelial cells released less IL-18 and IL-1β than cervical cancer cells.397 Sirtuin 1 (SIRT1) was overexpressed in HPV-infected cervical cancer cells, and knocking down SIRT1 caused cervical cancer cells to undergo pyroptosis, as well as highly express AIM2 and its downstream genes associated with the inflammasome response. The gene discussed is SIRT1; the disease is cervical cancer.