In addition, the high expression of GSDMD in lung adenocarcinoma indicated a poor prognosis.359 Gsdmd silencing in NSCLC cells decreased EGFR-AKT signaling, enhanced caspase-3 cleavage and apoptosis, and inhibited transplanted tumor growth in NSCLC cells in mice. This evidence concerns the gene GSDMD and non-small cell lung carcinoma.