GSDME and cancer: Compared with PTX, cisplatin induced more severe pyroptosis in non-small cell lung carcinoma and esophageal squamous cell carcinoma cells, suggesting that cisplatin may have more advantages than other drugs in treating cancer with high expression of GSDME.362,426 In addition, the expression of GSDME can enhance the tumor cell phagocytosis by tumor-associated macrophages and increase the number and function of tumor-infiltrating natural killer lymphocytes and CD8+ T lymphocytes.