Interestingly, knocking down LncRNA-XIST increased ROS level and activated NLRP3 inflammasome in A549 cells,383 and the generation of ROS was reported to induce pyroptosis.388–390 Besides, ROS scavenger N-acetyl cysteine (NAC) can block pyroptosis in NSCLC cell induced by the knock down of lncRNA-XIST, and the inhibition of cell proliferation can also be reversed by pyroptosis inhibitor necrosulfonamide (NSA).383 Generally, downregulation of lncRNA-XIST inhibits the development of NSCLC by activating miR-335/SOD2/ROS cascade-related pyroptosis.383. This evidence concerns the gene SOD2 and non-small cell lung carcinoma.