IGF2 and hepatocellular carcinoma: For instance, let-7i-5p had been found to not only inhibit hepatocellular carcinoma growth by targeting insulin-like growth factor 2-mRNA-binding proteins 1, 2, and 3 and the anti-apoptotic protein BCL2 like 1 [26, 27] but also rescue the tumor-suppressing effects of HDAC6 by targeting thrombospondin-1 in hepatocellular carcinoma cells [12].