CD40LG and Sepsis: Although the Surviving Sepsis Campaign guidelines advise against the use of IVIG in patients with sepsis or septic shock, given the lack of a statistical significance for survival benefits [9, 10], our recent positive outcome in treating septic shock with an IgM-enriched formulation as an adjuvant therapy [11] and the Gram-negative etiology of the patient’s condition were a convincing rationale, as IgM-enriched IVIGs were found to have higher antibody levels against Escherichiacoli and other Gram-negative bacteria than did normal IVIG preparations [12].