Besides, TIMP-1 has been suggested as a marker for abnormal regulation of matrix remodelling after a cardiovascular event in patients with type 1 diabetes.10 Moreover, elevated TIMP-1 plasma levels have been associated with the presence of left ventricular hypertrophy, of heart failure with signs of hypertrophy and myocardial fibrosis and dysfunction.29 Our study demonstrated significant correlations between TIMP-1 and impaired compound muscle action potential (CMAP) amplitude and sensory nerve action potential (SNAP). Here, TIMP1 is linked to hypertrophy.