Besides, TIMP-1 is earlier reported to correlate with known factors of structural renal injury such as microalbuminuria and increased values of Cystatin C and NGAL.30 It was found that increased values of TIMP-1 were associated with decreasing eGFR, remaining in normal renal function range, showing its predictive role in early renal dysfunction. This evidence concerns the gene LCN2 and Abnormal renal physiology.