DKK1 is significantly detectable in serum and inflamed synovium of RA patients overexpressing TNFα compared to healthy subjects and blocking DKK1 with specific antibodies protects from local bone resorption (reducing osteoclast numbers in the joints) and from negative DKK1 effects on osteoblastogenesis and osteoblast function, promoting bone repair [66]. The gene discussed is TNF; the disease is rheumatoid arthritis.