In univariable logistic regression analysis, the odds ratio (OR) of experiencing critical condition was significantly higher in patients with a higher CTSL level (OR, 1.53 per ng/ml; 95% CI, 1.19–1.96; P = 0.001) and older age (OR, 1.94 per 10 years; 95% CI, 1.31–2.88; P = 0.001), while CTSB, ACE2, Ang(1–7), sex, and coexistence of diabetes or hypertension did not significantly contribute to the odds of experiencing critical condition (Fig. 1g). This evidence concerns the gene ACE2 and Hypertension.