GPR126 also binds laminin-211,59 an extracellular matrix protein produced by astrocytes and present in the brain, with key roles in development and function of the blood-brain barrier,60 in part through regulation of pericyte differentiation, a mechanism previously implicated through the FOXF2 gene.61, 62 Small vessel disease-related endothelial dysfunction has also been shown to prevent oligodendrocyte precursor cell maturation, contributing to impaired myelination.63 This evidence concerns the gene FOXF2 and endothelial dysfunction.