It is possible that GFAP generally increases over time because of its significant correlation with age in both Aβ-negative and Aβ-positive groups (Aβ-: r = 0.57; Aβ+: r = 0.46); however, this could also suggest that higher concentrations of plasma GFAP are associated to general worsening in clinical symptoms, as the steepness of the increase in GFAP was greater in all groups that evolved to dementia. Here, GFAP is linked to dementia.