However, men who were overweight or obese were less likely to have an elevated PSA (RRoverweight: 0.89, 95% CI 0.80–0.99; RRobese: 0.75, 95% CI 0.65–0.85; p-trendfor continuous BMI < 0.0001), and no more likely to report a physician diagnosis of an enlarged prostate/BPH than normal weight men. Here, KLK3 is linked to benign prostatic hyperplasia.