Although some studies show higher expression of LC3 is correlated with higher growth for tumor cells, this indicated the autophagy markers LC3 and p62 are differentially expressed in NSCLC samples and high LC3 expression seem to be linked to lower tumor aggressiveness, while high p62 expression was significantly associated with aggressive tumor behavior (Schläfli et al., 2016). The gene discussed is MAP1LC3A; the disease is non-small cell lung carcinoma.