The second SNP to be discussed is SNP -238G>A in the TNF-α gene, its genotyping expressed that the frequency of the homozygous wild GG, heterozygous GA and homozygous mutant AA genotypes among HCV group were 11(15.7%), 15(21.4%), 44(62.9%) respectively versus 12 (15%), 11(13.8%), 57(71.3%) in the HCC group, showing no statistically significant association between the two studied groups. Here, TNF is linked to hepatocellular carcinoma.