IL18 and hepatocellular carcinoma: In accordance with this study, the study was done by Teixeira et al., (2013) reported a higher frequency of the IL-18 -607⁄A allele with (P = 0.0235) and -607AA genotype with (P = 0.0048 among HCC patients compared to healthy individuals, where the frequency of CA, AA, CC in patient with HCC were 56 (50%), 18 (16%),38 (34%) respectively and that in control group were 105(52%), 12(6%), 85(42%).