On the contrary to our results the study done by Teixeira et al., (2013) which was conducted on a total number of 314 Brazilian subjects they were divided into two groups, Group (1) Included 112 patients with hepatocellular carcinoma, group (2) included 202 healthy controls, they reported that TNFα -238/A allele showed significant susceptibility to HCC with (P = 0.0235), and that genotypes TNFα -238G>A were more frequent among patients with HCC compared to controls with (P = 0.0011). Here, TNF is linked to hepatocellular carcinoma.