Subgrouping was done to genotypes of SNP -607C>A in the IL18 gene into two different groups CC/CA versus AA showed that the AA genotype was more frequent in the HCC group 34(42.5%) versus HCV group 9(12.9%), (P<0.001), On performing odds ratio on the different genotype Subgroups of IL18 gene SNP-607C>A, it was found that individuals harboring the AA genotype were 5 folds riskier to develop HCC compared to those carrying the CC/CA genotypes (OR: 5). This evidence concerns the gene IL18 and hepatocellular carcinoma.