On comparing the frequency distribution of the SNP -607C>A in the IL18 gene among the two studied groups showed statistically significant association (P <0.001) where AA genotype showed higher percentage in HCC group versus HCV group (42.5% vs 12.9%) (P<0.001) as shown in Table 1, However TNF α gene polymorphism -238G>A showed no statistically significant association between the two studied groups. The gene discussed is IL18; the disease is hepatocellular carcinoma.