SOCS-1 and SOCS-3 genes are also negative regulators of JAK/STAT pathway, were down-regulated in MV4-11 leukemia cells and their re-expression by demethylation was associated with inhibition of JAK/STAT signaling and lower cell proliferation (Al-Jamal et al., 2015). The gene discussed is SOAT1; the disease is leukemia.