FGF1 and neoplasm: FGF-1 which was found to mediate tumor initiation, progression and metastasis, did not show significant changes in its expression levels when treating MCF-7 cells with miR-34a inhibitor with the tested compounds (Table 5).This opposes what happened when this cells was treated with compounds 2, 3, and 8 individually, as FGF-1 expression levels were significantly reduced (Yahya et al., 2017).