BCL2 and breast cancer: It also modulates drug sensitivity of breast cancer by affecting some of anti-apoptotic genes such as BCL-2 and CCND1. However, Kastl et al., (2012) reported that miR-34a over expression is associated with docetaxel resistance and enhance breast cancer stemness and drug resistance (Kim et al., 2016), on contrary, by having NOTCH 1 and PRKD1 as its targets, miR-34a affect chemoresistance of breast cancer cells to adriamycin (Li et al., 2012).