Moreover, over expression of miR-34a significantly down regulated survivin in HNSCC cell line, UM-SCC-74A (Kumar et al., 2012), in non-small cell lung cancer (NSCLC) cells (Ji et al., 2012), laryngeal squamous cell carcinoma cell lines (Cao et al., 2013), a gastric cancer cell line (Chen et al., 2010), murine melanoma cells (Shen et al. 2012). Here, BIRC5 is linked to melanoma.