CDH1 and neoplasm: They are a large family of zinc-dependent proteolytic enzymes that protelyse the extracellular matrix (ECM), regulate angiogenic factors, cleave E-cadherin to adjust the interactions between tumor cells, and process integrins to adjust the interaction between tumor cells and ECM, thus increasing the invasiveness of tumor cells (Nelson et al., 2000; Roy et al., 2009).