Fisette et al. demonstrated that rG4s in BACE1 exon 3 recruit hnRNP H to control BACE1 alternative splicing and the level of the BACE1 isoform that can proteolytically cleave APP to produce amyloid beta peptide (Aβ), which is linked to Alzheimer’s disease (162). This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.