BACE1 and Alzheimer disease: Fisette et al. demonstrated that rG4s in BACE1 exon 3 recruit hnRNP H to control BACE1 alternative splicing and the level of the BACE1 isoform that can proteolytically cleave APP to produce amyloid beta peptide (Aβ), which is linked to Alzheimer’s disease (162).